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KMID : 0359720150330020075
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Journal of the Korean Neurological Association
2015 Volume.33 No. 2 p.75 ~ p.81
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Extracellular Vesicles and Neurological Diseases
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Ho Dong-Hwan
Seo Hye-Myung
Son Il-Hong
Seol Won-Gi
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Abstract
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Extracellular vesicles (EVs) are small membranous vesicles that are secreted by various types of cells into biofluid or culture medium. EVs contain deoxyribonucleic acids, messenger ribonucleic acids (RNAs), microRNAs, lipids, and proteins derived from its cells of origin and can transfer those molecules to other targeted cells. Therefore, EVs can play important roles in intercellular communication. The findings of recent studies suggest that EVs can be used to spread protein aggregates in various neurodegenerative diseases such as Parkinson’s disease and Alzheimer’s disease. In addition, it has been recognized that EVs can be used as a material for detecting biomarkers for such diseases or as a therapeutic tool.
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KEYWORD
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Extracellular vesicle, Exosome, Biomarker
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